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Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles

The proteasome is responsible for the degradation of many cellular proteins. If and how this abundant and normally stable complex is degraded by cells is largely unknown. Here we show that in yeast, upon nitrogen starvation, proteasomes are targeted for vacuolar degradation through autophagy. Using...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Waite, Kenrick A., Mota-Peynado, Alina De-La, Vontz, Gabrielle, Roelofs, Jeroen
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751371/
https://ncbi.nlm.nih.gov/pubmed/26670610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699124
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