Intersection of population variation and autoimmunity genetics in human T cell activation

T lymphocyte activation by antigen conditions adaptive immune responses and immunopathologies, but we know little about its variation in humans, and its genetic or environmental roots. We analyzed gene expression in CD4(+) T cells during unbiased activation or in Th17 conditions from 348 healthy sub...

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Udgivet i:Science
Main Authors: Ye, Chun Jimmie, Feng, Ting, Kwon, Ho-Keun, Raj, Towfique, Wilson, Michael, Asinovski, Natasha, McCabe, Cristin, Lee, Michelle H., Frohlich, Irene, Paik, Hyun-il, Zaitlen, Noah, Hacohen, Nir, Stranger, Barbara, De Jager, Philip, Mathis, Diane, Regev, Aviv, Benoist, Christophe
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751028/
https://ncbi.nlm.nih.gov/pubmed/25214635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254665
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