Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase

Selective inhibitors of factor Xa (FXa) are widely recognized as useful therapeutic tools for stroke prevention in non-valvular atrial fibrillation or venous thrombosis. Thrombin, which is rapidly generated from pro-thrombin through the activation of factor X to FXa, acts as a potent activator of hu...

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Veröffentlicht in:PLoS One
Hauptverfasser: Tsujimoto, Masanori, Kuroyanagi, Gen, Matsushima-Nishiwaki, Rie, Kito, Yuko, Enomoto, Yukiko, Iida, Hiroki, Ogura, Shinji, Otsuka, Takanobu, Tokuda, Haruhiko, Kozawa, Osamu, Iwama, Toru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750972/
https://ncbi.nlm.nih.gov/pubmed/26867010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149077
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