AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: Suppression of HSP27 phosphorylation via p44/p42 MAP kinase

We have previously reported that collagen-induced phosphorylation of heat shock protein (HSP) 27 via p44/p42 mitogen-activated protein (MAP) kinase in human platelets is sufficient to induce the secretion of platelet-derived growth factor (PDGF)-AB and the release of soluble cluster of differentiati...

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Publicado en:Exp Ther Med
Main Authors: Tsujimoto, Masanori, Tokuda, Haruhiko, Kuroyanagi, Gen, Yamamoto, Naohiro, Kainuma, Shingo, Matsushima-Nishiwaki, Rie, Onuma, Takashi, Iida, Yuko, Kojima, Akiko, Sawada, Shigenobu, Doi, Tomoaki, Enomoto, Yukiko, Tanabe, Kumiko, Akamatsu, Shigeru, Iida, Hiroki, Ogura, Shinji, Otsuka, Takanobu, Kozawa, Osamu, Iwama, Toru
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950908/
https://ncbi.nlm.nih.gov/pubmed/27446328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2016.3435
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