HSP70 Inhibitor Suppresses IGF-I-Stimulated Migration of Osteoblasts through p44/p42 MAP Kinase

Heat shock protein 70 (HSP70) is a ubiquitously expressed molecular chaperone in a variety of cells including osteoblasts. We previously showed that insulin-like growth factor-I (IGF-I) elicits migration of osteoblast-like MC3T3-E1 cells through the activation of phosphatidylinositol 3-kinase/Akt an...

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Publié dans:Biomedicines
Auteurs principaux: Kawabata, Tetsu, Tokuda, Haruhiko, Sakai, Go, Fujita, Kazuhiko, Matsushima-Nishiwaki, Rie, Kuroyanagi, Gen, Otsuka, Takanobu, Kozawa, Osamu
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6316248/
https://ncbi.nlm.nih.gov/pubmed/30469446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines6040109
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