HSP90 inhibitors potentiate PGF(2α)-induced IL-6 synthesis via p38 MAP kinase in osteoblasts

Heat shock protein 90 (HSP90) that is ubiquitously expressed in various tissues, is recognized to be a major molecular chaperone. We have previously reported that prostaglandin F(2α) (PGF(2α)), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitoge...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fujita, Kazuhiko, Tokuda, Haruhiko, Kuroyanagi, Gen, Yamamoto, Naohiro, Kainuma, Shingo, Kawabata, Tetsu, Sakai, Go, Matsushima-Nishiwaki, Rie, Kozawa, Osamu, Otsuka, Takanobu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438147/
https://ncbi.nlm.nih.gov/pubmed/28542188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177878
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