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The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p

Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P). Sec2p also binds to the Sec4p effector Sec15p...

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Détails bibliographiques
Publié dans:Mol Biol Cell
Auteurs principaux: Stalder, Danièle, Novick, Peter J.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750927/
https://ncbi.nlm.nih.gov/pubmed/26700316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-09-0651
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