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Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53
Overexpression of the ankyrin repeat oncoprotein gankyrin is directly linked to the onset, proliferation and/or metastasis of many cancers. The role of gankyrin in multiple disease-relevant biochemical processes is profound. In addition to other cellular processes, gankyrin overexpression leads to d...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4750872/ https://ncbi.nlm.nih.gov/pubmed/25955581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00201 |
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