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Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling
Aseptic loosening is a major complication of prosthetic joint surgery, characterized by chronic inflammation, pain, and osteolysis surrounding the bone-implant interface. Progranulin (PGRN) is known to have anti-inflammatory action by binding to Tumor Necrosis Factor (TNF) receptors and antagonizing...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4750042/ https://ncbi.nlm.nih.gov/pubmed/26864916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20909 |
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