The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFR), and disturbed the TNFα/TNFR interaction. PGRN-defici...

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Detalhes bibliográficos
Main Authors: Tang, Wei, Lu, Yi, Tian, Qing-Yun, Zhang, Yan, Guo, Feng-Jin, Liu, Guang-Yi, Syed, Nabeel Muzaffar, Lai, Yongjie, Lin, Edward Alan, Kong, Li, Su, Jeffrey, Yin, Fangfang, Ding, Ai-Hao, Zanin-Zhorov, Alexandra, Dustin, Michael L., Tao, Jian, Craft, Joseph, Yin, Zhinan, Feng, Jian Q., Abramson, Steven B., Yu, Xiu-Ping, Liu, Chuan-ju
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104397/
https://ncbi.nlm.nih.gov/pubmed/21393509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1199214
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