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Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism

Alp14 is a TOG-family microtubule polymerase from S. pombe that tracks plus ends and accelerates their growth. To interrogate its mechanism, we reconstituted dynamically unstable single isoform S. pombe microtubules with full length Alp14/TOG and Alp7, the TACC-family binding partner of Alp14. We fi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hussmann, Frauke, Drummond, Douglas R., Peet, Daniel R., Martin, Douglas S., Cross, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749977/
https://ncbi.nlm.nih.gov/pubmed/26864000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20653
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