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Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism

Alp14 is a TOG-family microtubule polymerase from S. pombe that tracks plus ends and accelerates their growth. To interrogate its mechanism, we reconstituted dynamically unstable single isoform S. pombe microtubules with full length Alp14/TOG and Alp7, the TACC-family binding partner of Alp14. We fi...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Hussmann, Frauke, Drummond, Douglas R., Peet, Daniel R., Martin, Douglas S., Cross, Robert A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749977/
https://ncbi.nlm.nih.gov/pubmed/26864000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20653
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