Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. We examin...

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Vydáno v:Nat Commun
Hlavní autoři: Joubert, Bonnie R., den Dekker, Herman T., Felix, Janine F., Bohlin, Jon, Ligthart, Symen, Beckett, Emma, Tiemeier, Henning, van Meurs, Joyce B., Uitterlinden, Andre G., Hofman, Albert, Håberg, Siri E., Reese, Sarah E., Peters, Marjolein J., Kulle Andreassen, Bettina, Steegers, Eric A. P., Nilsen, Roy M., Vollset, Stein E., Midttun, Øivind, Ueland, Per M., Franco, Oscar H., Dehghan, Abbas, de Jongste, Johan C., Wu, Michael C., Wang, Tianyuan, Peddada, Shyamal D., Jaddoe, Vincent W. V., Nystad, Wenche, Duijts, Liesbeth, London, Stephanie J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749955/
https://ncbi.nlm.nih.gov/pubmed/26861414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10577
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