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Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice.

Depressed contractile function plays a primary role in the pathophysiology of acute myocardial ischemia. Intracellular acidification is an important factor underlying the inhibition of force production in the ischemic myocardium. The effect of acidosis to depress contractility is markedly greater in...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Metzger, J M, Parmacek, M S, Barr, E, Pasyk, K, Lin, W I, Cochrane, K L, Field, L J, Leiden, J M
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1993
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47496/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415650/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.19.9036
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