Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice.

Depressed contractile function plays a primary role in the pathophysiology of acute myocardial ischemia. Intracellular acidification is an important factor underlying the inhibition of force production in the ischemic myocardium. The effect of acidosis to depress contractility is markedly greater in...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Metzger, J M, Parmacek, M S, Barr, E, Pasyk, K, Lin, W I, Cochrane, K L, Field, L J, Leiden, J M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415650/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.19.9036
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