The kinetochore prevents centromere-proximal crossover recombination during meiosis

During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in huma...

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Veröffentlicht in:eLife
Hauptverfasser: Vincenten, Nadine, Kuhl, Lisa-Marie, Lam, Isabel, Oke, Ashwini, Kerr, Alastair RW, Hochwagen, Andreas, Fung, Jennifer, Keeney, Scott, Vader, Gerben, Marston, Adèle L
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2015
Schlagworte:
Genes and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749563/
https://ncbi.nlm.nih.gov/pubmed/26653857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10850
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