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The kinetochore prevents centromere-proximal crossover recombination during meiosis
During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in huma...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749563/ https://ncbi.nlm.nih.gov/pubmed/26653857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10850 |
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