Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes with ligands were determined at 2.8-A resolution. In a complex with edrophonium, and quaternary nitrogen of the lig...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Harel, M, Schalk, I, Ehret-Sabatier, L, Bouet, F, Goeldner, M, Hirth, C, Axelsen, P H, Silman, I, Sussman, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47495/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.19.9031
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