Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes with ligands were determined at 2.8-A resolution. In a complex with edrophonium, and quaternary nitrogen of the lig...

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Detalhes bibliográficos
Main Authors: Harel, M, Schalk, I, Ehret-Sabatier, L, Bouet, F, Goeldner, M, Hirth, C, Axelsen, P H, Silman, I, Sussman, J L
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC47495/
https://ncbi.nlm.nih.gov/pubmed/8415649
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