Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3

Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder caused by a CAG repeat expansion in the ataxin-3 (ATXN3) gene resulting in toxic protein aggregation. Inflammation and oxidative stress are considered secondary factors contributing to the progression of this neurodegenerative...

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Publicado no:Mol Med
Main Authors: Snijder, Pauline M, Baratashvili, Madina, Grzeschik, Nicola A, Leuvenink, Henri G D, Kuijpers, Lucas, Huitema, Sippie, Schaap, Onno, Giepmans, Ben N G, Kuipers, Jeroen, Miljkovic, Jan Lj, Mitrovic, Aleksandra, Bos, Eelke M, Szabó, Csaba, Kampinga, Harm H, Dijkers, Pascale F, den Dunnen, Wilfred F A, Filipovic, Milos R, van Goor, Harry, Sibon, Ody C M
Formato: Artigo
Idioma:Inglês
Publicado em: The Feinstein Institute Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749487/
https://ncbi.nlm.nih.gov/pubmed/26467707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00221
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