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Disease-causing SDHAF1 mutations impair transfer of Fe-S clusters to SDHB
SDHAF1 mutations cause a rare mitochondrial complex II (CII) deficiency, which manifests as infantile leukoencephalopathy with elevated levels of serum and white matter succinate and lactate. Here, we demonstrate that SDHAF1 contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subun...
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| Veröffentlicht in: | Cell Metab |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749439/ https://ncbi.nlm.nih.gov/pubmed/26749241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.12.005 |
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