An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke

Diabetes is a major risk factor for the development of stroke. Glucagon-like peptide-1 receptor (GLP-1R) agonists have been in clinical use for the treatment of diabetes and also been reported to be neuroprotective in ischemic stroke. The quinoxaline 6,7-dichloro-2-methylsulfonyl-3-N-tert- butylamin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Huinan, Liu, Yunhan, Guan, Shaoyu, Qu, Di, Wang, Ling, Wang, Xinshang, Li, Xubo, Zhou, Shimeng, Zhou, Ying, Wang, Ning, Meng, Jingru, Ma, Xue
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749391/
https://ncbi.nlm.nih.gov/pubmed/26863436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148827
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