E3 Ubiquitin Ligase Siah-1 is Down-regulated and Fails to Target Natural HBx Truncates for Degradation in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a common worldwide malignancy with high morbidity and mortality. Hepatitis B viral (HBV)-encoded X protein (HBx) and natural HBx variants play important roles in HBV-associated HCC development. HBx is an unstable protein that can be degraded in vivo. Our previous st...

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Bibliographic Details
Published in:J Cancer
Main Authors: Zhao, Jing, Wu, Jing, Cai, Hao, Wang, Dan, Yu, Long, Zhang, Wen-Hong
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749362/
https://ncbi.nlm.nih.gov/pubmed/26918055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.13019
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