Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials

The interferon gamma, enzyme-linked immunospot (IFN-γ ELISpot) assay is widely used to identify viral antigen-specific T cells is frequently employed to quantify T cell responses in HIV vaccine studies. It can be used to define T cell epitope specificities using panels of peptide antigens, but with...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fiore-Gartland, Andrew, Manso, Bryce A., Friedrich, David P., Gabriel, Erin E., Finak, Greg, Moodie, Zoe, Hertz, Tomer, De Rosa, Stephen C., Frahm, Nicole, Gilbert, Peter B., McElrath, M. Juliana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749288/
https://ncbi.nlm.nih.gov/pubmed/26863315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147812
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