HIV-1 Vaccine-Induced T-Cell Reponses Cluster in Epitope Hotspots that Differ from Those Induced in Natural Infection with HIV-1

Several recent large clinical trials evaluated HIV vaccine candidates that were based on recombinant adenovirus serotype 5 (rAd-5) vectors expressing HIV-derived antigens. These vaccines primarily elicited T-cell responses, which are known to be critical for controlling HIV infection. In the current...

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Detalhes bibliográficos
Main Authors: Hertz, Tomer, Ahmed, Hasan, Friedrich, David P., Casimiro, Danilo R., Self, Steven G., Corey, Lawrence, McElrath, M. Juliana, Buchbinder, Susan, Horton, Helen, Frahm, Nicole, Robertson, Michael N., Graham, Barney S., Gilbert, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688560/
https://ncbi.nlm.nih.gov/pubmed/23818843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003404
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