PHARMACOKINETIC EXPOSURE AND VIROLOGIC RESPONSE IN HIV-1 INFECTED PREGNANT WOMEN TREATED WITH LOPINAVIR/RITONAVIR: AIDS CLINICAL TRIALS GROUP PROTOCOL A5153S: A SUBSTUDY TO A5150

OBJECTIVE: We studied the pharmacokinetics and pharmacodynamics of boosted soft-gel lopinavir/ritonavir to assess if the area under the plasma concentration versus time curve (AUC) is altered in pregnancy and whether changes in AUC impacted HIV-1 control. METHODS: We enrolled pregnant women ≥13 year...

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Veröffentlicht in:Jacobs J AIDS HIV
Hauptverfasser: Sha, Beverly E., Tierney, Camlin, Sun, Xin, Stek, Alice, Cohn, Susan E., Coombs, Robert W., Bastow, Barbara, Aweeka, Francesca T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749161/
https://ncbi.nlm.nih.gov/pubmed/26878071
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