T-cell expression of IL10 is essential for tumor immune surveillance in the small intestine

IL10 is attributed with immune suppressive and anti-inflammatory properties, which could promote or suppress cancer in the gastrointestinal tract. Loss of IL10 exacerbates colonic inflammation leading to colitis and cancer. Consistent with this, transfer of IL10-competent regulatory T cells (Treg) i...

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Gepubliceerd in:Cancer Immunol Res
Hoofdauteurs: Dennis, Kristen L., Saadalla, Abdulrahman, Blatner, Nichole R., Wang, Shuya, Venkateswaran, Vysak, Gounari, Fotini, Cheroutre, Hilde, Weaver, Casey T., Roers, Axel, Egilmez, Nejat K., Khazaie, Khashayarsha
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749132/
https://ncbi.nlm.nih.gov/pubmed/25855122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0169
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