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Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway
Rgs2, a regulator of G proteins, lowers blood pressure by decreasing signaling through Gα(q). Human patients expressing Met-Leu-Rgs2 (ML-Rgs2) or Met-Arg-Rgs2 (MR-Rgs2) are hypertensive relative to people expressing wild-type Met-Gln-Rgs2 (MQ-Rgs2). We found that wild-type MQ-Rgs2 and its mutant, MR...
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| Gepubliceerd in: | Science |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4748709/ https://ncbi.nlm.nih.gov/pubmed/25766235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa3844 |
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