Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

Cognitive dysfunction is a core feature of dementia and a prominent feature in psychiatric disease. As non-redundant regulators of intracellular cAMP gradients, phosphodiesterases (PDE) mediate fundamental aspects of brain function relevant to learning, memory, and higher cognitive functions. Phosph...

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Bibliographic Details
Published in:Neuropsychopharmacology
Main Authors: McGirr, Alexander, Lipina, Tatiana V, Mun, Ho-Suk, Georgiou, John, Al-Amri, Ahmed H, Ng, Enoch, Zhai, Dongxu, Elliott, Christina, Cameron, Ryan T, Mullins, Jonathan GL, Liu, Fang, Baillie, George S, Clapcote, Steven J, Roder, John C
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748432/
https://ncbi.nlm.nih.gov/pubmed/26272049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.240
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