Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice

BACKGROUND: Schizophrenia is a neurodevelopmental disorder with onset early in adulthood. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptibility gene for schizophrenia and other psychiatric disorders. Disc1-L100P mutant mice show behaviors relevant to schizophrenia at 12 weeks, but not at 8 weeks...

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Hauptverfasser: Lipina, Tatiana V., Haque, Fahmida Nipa, McGirr, Alexander, Boutros, Paul C., Berger, Thorsten, Mak, Tak W., Roder, John C., Wong, Albert H. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525594/
https://ncbi.nlm.nih.gov/pubmed/23272119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051562
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