AKT signaling in ERBB2-amplified breast cancer

The PI3K/AKT pathway is the focus of several targeted therapeutic agents for a variety of malignancies. In ERBB2-amplified breast cancer, the hyperactivation of this signaling cascade is associated with resistance to ERBB2-targeted therapy. This can occur through gain-of-function alterations or comp...

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發表在:Pharmacol Ther
Main Authors: Carmona, F Javier, Montemurro, Filippo, Kannan, Srinivasaraghavan, Rossi, Valentina, Verma, Chandra, Baselga, José, Scaltriti, Maurizio
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747800/
https://ncbi.nlm.nih.gov/pubmed/26645663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2015.11.013
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