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AKT signaling in ERBB2-amplified breast cancer
The PI3K/AKT pathway is the focus of several targeted therapeutic agents for a variety of malignancies. In ERBB2-amplified breast cancer, the hyperactivation of this signaling cascade is associated with resistance to ERBB2-targeted therapy. This can occur through gain-of-function alterations or comp...
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| Publicado no: | Pharmacol Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747800/ https://ncbi.nlm.nih.gov/pubmed/26645663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2015.11.013 |
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