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Amplification-free In Situ KRAS Point Mutation Detection at 60 copies/mL in Urine in a Background of 1000-fold Wild Type
We have examined in situ detection of single-nucleotide KRAS mutation in urine using a (Pb(Mg(1/3)Nb(2/3))O(3))(0.65)(PbTiO(3))(0.35) (PMN-PT) piezoelectric plate sensor (PEPS) coated with a 17-nucleotide (nt) locked nucleic acid (LNA) probe DNA complementary to the KRAS mutation. To enhance in situ...
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| Publicado en: | Analyst |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747796/ https://ncbi.nlm.nih.gov/pubmed/26783561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5an02048d |
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