S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification

Blunting immunopathology without abolishing host defense is the foundation for safe and effective modulation of infectious and autoimmune diseases. Sphingosine 1-phosphate receptor 1 (S1PR1) agonists are effective in treating infectious and multiple autoimmune pathologies; however, mechanisms underl...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Teijaro, John R., Studer, Sean, Leaf, Nora, Kiosses, William B., Nguyen, Nhan, Matsuki, Kosuke, Negishi, Hideo, Taniguchi, Tadatsugu, Oldstone, Michael B. A., Rosen, Hugh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747766/
https://ncbi.nlm.nih.gov/pubmed/26787880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525356113
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