Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo

HLA-A is a class I major histocompatibility complex receptor that presents peptide antigens on the surface of most cells. Vitiligo, an autoimmune disease in which skin melanocytes are destroyed by cognate T cells, is associated with variation in the HLA-A gene; specifically HLA-A*02:01, which presen...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Hayashi, Masahiro, Jin, Ying, Yorgov, Daniel, Santorico, Stephanie A., Hagman, James, Ferrara, Tracey M., Jones, Kenneth L., Cavalli, Giulio, Dinarello, Charles A., Spritz, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747738/
https://ncbi.nlm.nih.gov/pubmed/26787886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525001113
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