Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8(+) T cells in aged mice

In advanced age, decreased CD8(+) cytotoxic T-lymphocyte (CTL) responses to novel pathogens and cancer is paralleled by a decline in the number and function of naïve CTL precursors (CTLp). Although the age-related fall in CD8(+) T-cell numbers is well established, neither the underlying mechanisms n...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Quinn, Kylie M., Zaloumis, Sophie G., Cukalac, Tania, Kan, Wan-Ting, Sng, Xavier Y. X., Mirams, Michiko, Watson, Katherine A., McCaw, James M., Doherty, Peter C., Thomas, Paul G., Handel, Andreas, La Gruta, Nicole L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747731/
https://ncbi.nlm.nih.gov/pubmed/26787864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525167113
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