Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

CD8(+) T cell responses to viral infection are characterized by the emergence of dominant and subdominant CTL populations. The immunodominance hierarchies of these populations are highly reproducible for any given spectrum of virus-induced peptide-MHCI complexes and are likely determined by multiple...

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Detalhes bibliográficos
Main Authors: La Gruta, Nicole L., Rothwell, William T., Cukalac, Tania, Swan, Natasha G., Valkenburg, Sophie A., Kedzierska, Katherine, Thomas, Paul G., Doherty, Peter C., Turner, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877949/
https://ncbi.nlm.nih.gov/pubmed/20440073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41538
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