Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes

The architecture of higher-order chromatin in eukaryotic cell nuclei is largely unknown. Here, we use electron microscopy-assisted nucleosome interaction capture (EMANIC) cross-linking experiments in combination with mesoscale chromatin modeling of 96-nucleosome arrays to investigate the internal or...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Grigoryev, Sergei A., Bascom, Gavin, Buckwalter, Jenna M., Schubert, Michael B., Woodcock, Christopher L., Schlick, Tamar
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747710/
https://ncbi.nlm.nih.gov/pubmed/26787893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518280113
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