Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification

Filamentation induced by cyclic AMP (FIC)-domain enzymes catalyze adenylylation or other posttranslational modifications of target proteins to control their function. Recently, we have shown that Fic enzymes are autoinhibited by an α-helix (α(inh)) that partly obstructs the active site. For the sing...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Stanger, Frédéric V., Burmann, Björn M., Harms, Alexander, Aragão, Hugo, Mazur, Adam, Sharpe, Timothy, Dehio, Christoph, Hiller, Sebastian, Schirmer, Tilman
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747691/
https://ncbi.nlm.nih.gov/pubmed/26787847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516930113
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