p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism

The reduced movement repertoire of Parkinson’s disease (PD) is mainly due to degeneration of nigrostriatal dopamine neurons. Restoration of dopamine transmission by levodopa (L-DOPA) relieves motor symptoms of PD but often causes disabling dyskinesias. Subchronic L-DOPA increases levels of adaptor p...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Schintu, Nicoletta, Zhang, Xiaoqun, Alvarsson, Alexandra, Marongiu, Roberta, Kaplitt, Michael G., Greengard, Paul, Svenningsson, Per
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747690/
https://ncbi.nlm.nih.gov/pubmed/26787846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524303113
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