p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism

The reduced movement repertoire of Parkinson’s disease (PD) is mainly due to degeneration of nigrostriatal dopamine neurons. Restoration of dopamine transmission by levodopa (L-DOPA) relieves motor symptoms of PD but often causes disabling dyskinesias. Subchronic L-DOPA increases levels of adaptor p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schintu, Nicoletta, Zhang, Xiaoqun, Alvarsson, Alexandra, Marongiu, Roberta, Kaplitt, Michael G., Greengard, Paul, Svenningsson, Per
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747690/
https://ncbi.nlm.nih.gov/pubmed/26787846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524303113
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