Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease. Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry. There is a need for small-animal models of MERS, but mice are not susceptible to MERS because murine dpp4 does not serve as a receptor. W...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Li, Kun, Wohlford-Lenane, Christine, Perlman, Stanley, Zhao, Jincun, Jewell, Alexander K., Reznikov, Leah R., Gibson-Corley, Katherine N., Meyerholz, David K., McCray, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747621/
https://ncbi.nlm.nih.gov/pubmed/26486634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv499
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