Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling

The role of death receptor 5 (DR5), a well-known cell surface pro-apoptotic protein, in the negative regulation of invasion and metastasis of human cancer cells and the underlying mechanisms are largely unknown and were hence the focus of this study. In this report, we have demonstrated that DR5 fun...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Oh, You-Take, Yue, Ping, Wang, Dongsheng, Tong, Jing-Shan, Chen, Zhuo G., Khuri, Fadlo R., Sun, Shi-Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747408/
https://ncbi.nlm.nih.gov/pubmed/26510914
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