The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5

Carfilzomib (CFZ) is a second generation proteasome inhibitor approved for the treatment of patients with multiple myeloma. It induces apoptosis in human cancer cells; but the underlying mechanisms remain undefined. In the present study, we show that CFZ decreases the survival of several human cance...

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Vydáno v:Oncotarget
Hlavní autoři: Han, Bo, Yao, Weilong, Oh, You-Take, Tong, Jing-Shan, Li, Shaohua, Deng, Jiusheng, Yue, Ping, Khuri, Fadlo R., Sun, Shi-Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627326/
https://ncbi.nlm.nih.gov/pubmed/26009898
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