Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin

Galectins are small soluble lectins that bind β-galactosides via their carbohydrate recognition domain (CRD). Their ability to dimerize is critical for the crosslinking of glycoprotein receptors and subsequent cellular signaling. This is particularly important in their immunomodulatory role via the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vladoiu, Maria Claudia, Labrie, Marilyne, Létourneau, Myriam, Egesborg, Philippe, Gagné, Donald, Billard, Étienne, Grosset, Andrée-Anne, Doucet, Nicolas, Chatenet, David, St-Pierre, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747383/
https://ncbi.nlm.nih.gov/pubmed/26543238
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