Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway

Disulfiram (DSF), an anti-alcoholism drug, has been reported as an inhibitor of NF-κB. NF-κB is involved in epithelial-mesenchymal transition (EMT) and self-renewal of breast cancer stem cells (CSCs). In this study, we treated MCF-7 and MDA-MB-231 breast cancer cells with TGF-β to induce EMT and can...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Han, Dan, Wu, Gang, Chang, Chan, Zhu, Fang, Xiao, Yin, Li, Qiuhui, Zhang, Tao, Zhang, Liling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747377/
https://ncbi.nlm.nih.gov/pubmed/26517513
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