Disulfiram inhibits epithelial–mesenchymal transition through TGFβ–ERK–Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis

Purpose: Smad4 loss is highly related to poor prognosis and decreased patient survival in oral squamous cell carcinoma (OSCC), suggesting that agents that target both Smad4-mutated and Smad4 wild-type cells could treat OSCC more effectively. Disulfiram (Dsf) has anticancer activity through a variety...

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Bibliographic Details
Published in:	Cancer Manag Res
Main Authors:	Bu, Wenhuan, Wang, Zilin, Meng, Lin, Li, Xing, Liu, Xinchen, Chen, Yumeng, Xin, Ying, Li, Baoquan, Sun, Hongchen
Format:	Artigo
Language:	Inglês
Published:	Dove 2019
Subjects:	Original Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6504671/ https://ncbi.nlm.nih.gov/pubmed/31118804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S199912
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Disulfiram inhibits epithelial–mesenchymal transition through TGFβ–ERK–Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis

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