Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein

A chromosomal translocation results in production of an oncogenic PAX8-PPARG fusion protein (PPFP) in thyroid carcinomas. PAX8 is a thyroid transcription factor, and PPARG is a transcription factor that plays important roles in adipocytes and macrophages. PPFP retains the DNA binding domains of both...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zhang, Yanxiao, Yu, Jingcheng, Lee, Chee, Xu, Bin, Sartor, Maureen A., Koenig, Ronald J.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747342/
https://ncbi.nlm.nih.gov/pubmed/26595524
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