Pioglitazone Therapy of PAX8-PPARγ Fusion Protein Thyroid Carcinoma

CONTEXT: A subset of thyroid carcinomas expresses an oncogenic paired box 8 (PAX8) and peroxisome proliferator activated receptor γ (PPARγ) fusion protein (PPFP). The PPARγ/PPFP ligand pioglitazone is highly therapeutic in a transgenic mouse model of PPFP thyroid carcinoma, but whether pioglitazone...

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Bibliografiske detaljer
Udgivet i:J Clin Endocrinol Metab
Main Authors: Giordano, Thomas J, Haugen, Bryan R, Sherman, Steven I, Shah, Manisha H, Caoili, Elaine M, Koenig, Ronald J
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2018
Fag:
Case Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456920/
https://ncbi.nlm.nih.gov/pubmed/29373711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-02533
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