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Mutational profiling of colorectal cancers with microsatellite instability

Microsatellite instability (MSI) is caused by defective mismatch repair in 15–20% of colorectal cancers (CRCs). Higher mutation loads in tumors with mismatch repair deficiency can predict response to pembrolizumab, an anti-programmed death 1 (PD-1) immune checkpoint inhibitor. We analyzed the mutati...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Lin, Elaine I., Tseng, Li-Hui, Gocke, Christopher D., Reil, Stacy, Le, Dung T., Azad, Nilofer S., Eshleman, James R.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747229/
https://ncbi.nlm.nih.gov/pubmed/26517354
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