Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with (89)Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts

Mesothelin is a tumor differentiation antigen expressed by epithelial tumors, including pancreatic cancer. Currently, mesothelin is being targeted with an antibody-drug conjugate (ADC) consisting of a mesothelin-specific antibody coupled to a highly potent chemotherapeutic drug. Considering the toxi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: ter Weele, Eva J., van Scheltinga, Anton G.T. Terwisscha, Kosterink, Jos G.W., Pot, Linda, Vedelaar, Silke R., Lamberts, Laetitia E., Williams, Simon P., Hooge, Marjolijn N. Lub-de, de Vries, Elisabeth G.E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747211/
https://ncbi.nlm.nih.gov/pubmed/26536664
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